Uses / Indications: Bevaro 400mg Injection is indicated to treat the following conditions: • Glioblastoma multiforme (brain cancer) • Persistent, recurrent, or metastatic breast cancer • Metastatic cervical cancer • Advanced kidney cancer • Metastatic colorectal cancer • Advanced non-small-cell lung cancer • Liver Cancer- Hepatocellular carcinoma • Cancers of the ovary, cervical, fallopian tube, or primary peritoneal cancer

Product composition:
• BEVACIZUMAB

Pregnancy interaction:
• Pregnancy (unsafe): Inform your physician before starting your treatment with Bevaro 400mg Injection in case, if you are pregnant or planning for pregnancy as this medicine may cause harm to the unborn baby and interrupt the formation of blood vessels.

Expert advice:
• It is vital to inform your physician before taking Bevaro 400mg Injection if you have the following conditions: • Have conditions involving inflammation in the stomach (ulcer, colitis). • Experience allergic reactions to Bevaro 400mg Injection or its ingredients. • Have recently undergone surgery as it is associated with the risk of bleeding. • Have diabetes, hypertension, or heart problems.

Side Effects:
• Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them. Serious: • Headache • Vision changes • Confusion • Severe allergic reactions • High Blood pressure • Delayed wound healing following surgery • Protein in urine • Severe infections • Blood clots in arteries and blood vessels of lungs • Gut perforation • Nosebleeds and bleeding risk • Heart problems with an increase in heart rate • Mouth sores, dryness • Shortness of breath Common: • Numbness in hands or feet • Weakness and lack of energy • Diarrhoea, nausea, vomiting, abdominal pain • Constipation • Loss of appetite • Weight loss • Changes in taste and speech • Decrease in counts of white blood cells • Fever • Dry skin • Back pain

How to use:
• Your physician or nurse will administer Bevaro 400mg Injection as an intravenous infusion. The infusion should be given immediately after the dilution.

How it works:
• Bevaro 400mg Injection is a recombinant humanized monoclonal antibody that works as a targeted therapy in the treatment of various advanced cancers. It produces its action by selectively binding to the protein called vascular endothelial growth factor A (VEGF-A), present in the lining of blood and lymph vessels in the body. It interrupts the interaction of VEGF-A with its receptors. This further inhibits the formation of blood vessels that supply oxygen and nutrients to the tumor. As a result, it slows down the rate of progression of cancer.

Faq for medicine:
• Q: Is Bevaro 400mg Injection used as standalone treatment in cancers? A: Bevaro 400mg Injection is a recombinant monoclonal antibody that belongs to the immunotherapy class of cancer treatment. It can either be used as monotherapy or in combination with chemotherapy or immunotherapy medications to improve the overall survival rate. Q: Is it safe for women to use Bevaro 400mg Injection? A: While for women with reproductive potential subjected to Bevaro 400mg Injection, it is advised to discuss with your doctor regarding the effective birth control methods during the treatment. Also to be continued for a minimum of 6 months after the treatment course completion as this medicine may impair fertility. Q: Is it safe to undergo a surgery during the treatment with Bevaro 400mg Injection? A: Bevaro 400mg Injection is associated with increased risk of bleeding complications and poor wound healing. Hence it is suggested to avoid planning for surgery and maintain an interval of 28days before or after surgery. Q: Do the side effects of Bevaro 400mg Injection last for a chronic period? A: All the side effects that are relatively caused by Bevaro 400mg Injection occur until the drug concentration stays in the body. It is found that this medicine will be contained in our body for almost 4 months after the final dose. Q: How is Bevaro 400mg Injection administered? A: Bevaro 400mg Injection is given intravenously through infusion and the amount of drug will be measured based on the patient’s body weight, height and age.  The first dose will be administered for 90 minutes and if well tolerated the infusion time can be reduced to 30 minutes. Q: Can I take Bevaro 400mg Injection if I am pregnant? A: Inform your physician before starting your treatment with Bevaro 400mg Injection in case, if you are pregnant or planning for pregnancy as this medicine may cause harm to the unborn baby and interrupt the formation of blood vessels.

Medicine interaction:
• Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional and vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with Bevaro 400mg Injection and cause undesirable side effects.